Epclusa is used to treat chronic hepatitis C in adults with genotypes 1, 2, 3, 4, 5, or 6. It is the first hepatitis C medication that can successfully treat all six genotypes. Epclusa Cost in India is a two-drug combination administered as a single daily pill containing the viral NS5A inhibitor Velpatasvir and Sofosbuvir. The treatment duration is 12 weeks for all genotypes. No ribavirin for most patients. It is used on its own in patients without cirrhosis or with compensated cirrhosis and in combination with ribavirin in patients with decompensated cirrhosis. Sofosbuvir–velpatasvir (Epclusa, Gilead) is a fixed-dose combination drug. Sofosbuvir inhibits hepatitis C virus (HCV) nonstructural viral protein NS5B ribonucleic acid (RNA)-dependent RNA polymerase. Velpatasvir inhibits hepatitis C non-structural protein NS5A. Most people don’t experience significant side effects – but if they do the most common adverse reactions observed with treatment with Epclusa for 12 weeks are headache and fatigue. The most common adverse reactions observed with treatment with Epclusa and ribavirin for 12 weeks in patients with decompensated cirrhosis are fatigue, anemia, nausea, headache, insomnia, and diarrhea.
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